Network Analysis of IPF-Related Genes Regulated by DLP and DHP

Networks analysis of the targeted IPF related genes regulated by DLP and DHP were performed as described in our previous study (Lyu et al., 2017 (link), 2018 (link)). The main source of disease targets for IPF was obtained from IPA¹ database. According to our previous study (Dong J. et al., 2013), 15 compounds used as marker substances of DLP were uploaded into the IPA system to enable the discovery visualization, including gallic acid, puerarin, daidzin, peoniflorin, naringin, rosmarinic acid, salvianolic acid A, formononetin, calycosin, ethyl gallate, lipoteichoic acid, chlorogenic acid, ferulic acid, cryptotanshinone and tanshinone IIA. Similarly, 14 compound were chosen as major ingredients of DHP for IPA analysis, such as L-proline, L-phenylalanine, caffeic acid, danshensu, rutin, hydroxysafflor yellow A, safflor yellow A, salvianolic acid B, uridine, syringin, chlorogenic acid, ferulic acid, rosmarinic acid, salvianolic acid A (Liu et al., 2013 (link)). “Build-Path Explorer” module was applied to discover IPF-related targets, and the relationship between the targets and DLP or DHP ingredients, respectively.

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Shao R., Wang F.J., Lyu M., Yang J., Zhang P, & Zhu Y. (2019). Ability to Suppress TGF-β-Activated Myofibroblast Differentiation Distinguishes the Anti-pulmonary Fibrosis Efficacy of Two Danshen-Containing Chinese Herbal Medicine Prescriptions. Frontiers in Pharmacology, 10, 412.

Publication 2019

Caffeic acid Calycosin Chlorogenic acid Cryptotanshinone Daidzin Danshensu Ethyl gallate Ferulic acid Formononetin Gallic acid Hydroxysafflor yellow a L phenylalanine L proline Lipoteichoic acid Naringin Peoniflorin Puerarin Rosmarinic acid Rutin Salvianolic acid a Salvianolic acid b Syringin Tanshinone iia Targeted genes analysis Uridine

Corresponding Organization : Tianjin International Joint Academy of Biomedicine

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Variable analysis

independent variables

15 compounds used as marker substances of DLP
14 compounds chosen as major ingredients of DHP

dependent variables

IPF-related targets
Relationship between the targets and DLP or DHP ingredients

control variables

Not explicitly mentioned

controls

No positive or negative controls are specified by the authors.

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