Wistar Rat Contrast Agent Study

In the experiments, 70 Wistar albino male rats weighing 250-280 g obtained from the Experimental Animal Laboratory of Medicinal and Experimental Application and Research Center were used. The animals were housed under controlled conditions at 22 ± 1°C and 12-hour light–12-hour darkness cycles in standard plastic cages. Rat food pellets and water were provided ad libitum. Gadodiamide was used as a contrast agent (Omniscan, Opakim Pharma, Istanbul, Turkey), and 50 mg/mL ketamine (Ketalar, Pfizer, Istanbul, Turkey) and 100 mg/mL xylazine (XYLASED, Bioveta, Ankara, Turkey) were used as dissociative anesthetics.

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Alper F., Karaman A., Yalçın A., Atila A., Dincer B., Sirinoglu B.D., Kaya S, & Tavaci T. (2024). Temporal Assessment of Gadolinium Deposition and T1 Signal Intensity Changes in Rat Kidney with Single and Multiple Doses of Injection: An Experimental Study. The Eurasian Journal of Medicine, 56(1), 47-51.

Publication 2024

Ketalar

Corresponding Organization :

Other organizations : Atatürk University, Erzincan University

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Variable analysis

independent variables

Gadodiamide (contrast agent)

dependent variables

Not explicitly mentioned

control variables

Wistar albino male rats weighing 250-280 g
Controlled temperature at 22 ± 1°C
12-hour light–12-hour darkness cycles
Rat food pellets and water provided ad libitum

controls

No positive or negative controls were explicitly mentioned

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