Assessing Motor Coordination in Rodents

The Rotarod is a motor-coordination test, which consists of a rotating drum (Ugo Basile, model 47600, Comerio, Italy), in which animals are placed, while the drum is accelerating from 4 to 40 rpm. Maximal velocity is achieved after 260 s (maximum testing time 300 s). The time until each animal drops off the drum is measured [23 (link), 24 (link)]. Animals were trained three times each on three consecutive days before MCAO. Following a baseline evaluation, animals were tested at 3 days, 7 days and then weekly until 56 day post-MCAO.

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Yin D., Wang C., Qi Y., Wang Y.C., Hagemann N., Mohamud Yusuf A., Dzyubenko E., Kaltwasser B., Tertel T., Giebel B., Gunzer M., Popa-Wagner A., Doeppner T.R, & Hermann D.M. (2023). Neural precursor cell delivery induces acute post-ischemic cerebroprotection, but fails to promote long-term stroke recovery in hyperlipidemic mice due to mechanisms that include pro-inflammatory responses associated with brain hemorrhages. Journal of Neuroinflammation, 20, 210.

Publication 2023

model 47600

Animals

Corresponding Organization :

Other organizations : University of Duisburg-Essen

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Variable analysis

independent variables

Days post-MCAO (baseline, 3 days, 7 days, weekly until 56 days)

dependent variables

Time until the animal drops off the rotating drum

control variables

Rotating drum (Ugo Basile, model 47600, Comerio, Italy)
Drum acceleration from 4 to 40 rpm over 260 seconds
Maximum testing time of 300 seconds
Training of animals three times each on three consecutive days before MCAO

controls

Baseline evaluation before MCAO

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