High-resolution, three-dimensional spoiled gradient-recalled at steady-state (SPGR) anatomic images were acquired on a General Electric (Waukesha, WI) Signa Excite 3.0 Tesla short bore scanner equipped with a quad split quadrature transmit/receive head coil (TE = 3.9 ms; TR = 9.5 ms; inversion recovery (IR) preparation time = 450 ms; flip angle = 12°; number of excitations (NEX) = 2; slice thickness = 1.0 mm; FOV = 24 cm; resolution = 256 × 224). A scanner upgrade took place near the end of the final retest period. Six ε4+ participants and one ε4- had their third scan conducted on a GE MR750 3.0 Tesla scanner (TE = 3.9 ms; TR = 9.6 ms; inversion recovery (IR) preparation time = 450 ms; flip angle = 12°; number of excitations (NEX)=1; slice thickness = 1.0 mm; FOV = 24 cm; resolution=256×224). A between-scanner comparison showed no systematic differences. Whole brain and regional volumes were derived from T1- weighted SPGR images using the longitudinal stream in Freesurfer v.5.1 software [23 (link)].
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3T MRI brain morphometry protocol
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Corresponding Organization : Cleveland Clinic
Other organizations : Marquette University, Medical College of Wisconsin, Wayne State University, University of Maryland, College Park, Rosalind Franklin University of Medicine and Science
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Variable analysis
independent variables
- Scanner upgrade (Signa Excite 3.0 Tesla vs. GE MR750 3.0 Tesla)
- Whole brain and regional volumes derived from T1-weighted SPGR images
- TE (3.9 ms)
- TR (9.5 ms for Signa Excite, 9.6 ms for GE MR750)
- Inversion recovery (IR) preparation time (450 ms)
- Flip angle (12°)
- Number of excitations (NEX) (2 for Signa Excite, 1 for GE MR750)
- Slice thickness (1.0 mm)
- Field of view (FOV) (24 cm)
- Resolution (256 × 224)
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