AlphaFold multimer version 2.1.236 (link),37 (link) with its default parameters was used to generate the ML-PAPP-A2/IGFBP5 model. The mature versions of PAPP-A2 with signal peptide and pro-peptide regions removed and IGFBP5 with signal peptide region removed were as inputs for AlphaFold multimer.
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