Subjects were genotyped using the HumanOmniExpress array (Illumina) employing BeadStudio quality control, which included reclustering on project samples following Illumina guidelines, as previously described for COPDGene. Genotype imputation was performed using the Michigan Imputation Server and the HRC 1.1 reference NHW and the 1000 Genome Phase 1 v3 for AAs.35 (link) Ancestry-based principal components (PCs) were calculated and used as previously described.36 (link),37 (link) Variants were filtered to include only single-nucleotide polymorphisms (SNPs) with minor allele frequencies >1% in the sample population.
Corresponding Organization : University of Colorado Anschutz Medical Campus
Other organizations :
Brigham and Women's Hospital, Colorado School of Public Health, Johns Hopkins University, Agilent Technologies (United States), University of Michigan–Ann Arbor, University of North Carolina at Chapel Hill, Lung Institute, Wake Forest University, Minneapolis VA Medical Center, University of Minnesota
Genotyping using the HumanOmniExpress array (Illumina) employing BeadStudio quality control
Genotype imputation using the Michigan Imputation Server and the HRC 1.1 reference NHW and the 1000 Genome Phase 1 v3 for AAs
dependent variables
Not explicitly mentioned
control variables
Reclustering on project samples following Illumina guidelines
Ancestry-based principal components (PCs) calculated and used as previously described
Variants filtered to include only single-nucleotide polymorphisms (SNPs) with minor allele frequencies >1% in the sample population
positive controls
Not specified
negative controls
Not specified
Annotations
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