Evaluating Sleep Quality and Alzheimer's Risk

Last, we replicated analyses from an earlier WRAP PET publication.^{20 (link)} That study showed significant yet small associations between less adequate sleep, more sleep problems and greater SOM on the MOS and greater amyloid PET burden in Alzheimer’s disease–sensitive brain regions among 98 cognitively unimpaired adults (aged 62.4 ± 5.7 years) at their fourth WRAP visit. Participants were identified for the present analysis if they had completed WRAP Visit 4 (including sleep assessment), had completed a PiB PET scan and were non-demented; 315 individuals met these inclusion criteria. To match with the data set in Sprecher et al., we then excluded 95 people, leaving a sample size n = 220. We performed the same linear regression previously performed in Sprecher et al.,^{20 (link)} including age, sex, APOE e4 genotype, family history of Alzheimer’s disease and BMI as covariates.