In this retrospective cohort study, we analyzed database obtained from the Registry for Catastrophic Illness Patients (CIPR), which consists of disease categories including ESRD, with verifying chronic dialysis and the irreversible status by two nephrologists. The data represented a subset of the National Health Insurance Research Database (NHIRD) covering a period from 1 January 2000, to 31 December 2016 (National Science Council—Taiwan, RRID: SCR_011434). The NHIRD, with comprehensive records of claims relating to outpatient and inpatient medical care, enrolled data from 23 million Taiwanese people as in 2015 [16 ,17 ]. The RCID comprises information on the registry of beneficiaries, diagnostic codes, medical procedures, and prescription data. All data extracted from the NHIRD were deidentified to protect privacy.
Definitions of diseases are based on the International Classification of Diseases, 9th Revision, Clinical Modification for cases diagnosed before 1 January 2016 and the International Classification of Diseases, 10th Revision, Clinical Modification for cases diagnosed afterwards. The list of ICD-9 and ICD-10 codes were used to define the inclusion criteria for patients on dialysis, outcome events, and comorbidities as shown inSupplemental File S1: Table S1 .
Definitions of diseases are based on the International Classification of Diseases, 9th Revision, Clinical Modification for cases diagnosed before 1 January 2016 and the International Classification of Diseases, 10th Revision, Clinical Modification for cases diagnosed afterwards. The list of ICD-9 and ICD-10 codes were used to define the inclusion criteria for patients on dialysis, outcome events, and comorbidities as shown in
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