DNA Methylation Analysis of Depression

DNA methylation data for depression was extracted from the Gene Expression Omnibus (GEO) with the accession number GSE128235. The data consisted of 324 depressed and 209 healthy participants of European ethnicity recruited from the Max Planck Institute of Psychiatry. Depressed individuals were diagnosed using the Diagnostic and Statistical Manual of Mental Disorder (DSM) IV criteria. The demographic information of this cohort is shown in Table 1. Methylation profiles were obtained using the Illumina HumanMethylation450 BeadChip (450K), of which the details have been previously described (Zannas et al., 2019 (link)).