Antihypertensive Effects on PVS Volumes

Antihypertensive medications were recorded at each study visit and exposure to each class was calculated as the fraction of days taking the antihypertensive from randomization to follow-up MRI. To test the effects of antihypertensive classes on PVS volumes, some classes were combined: ACE inhibitors and angiotensin receptor blockers, selective and non-selective beta blockers, dihydropyridine and non-dihydropyridine calcium channel blockers, and diuretics including thiazide, loop, and potassium-sparing.

Free full text: Click here

Kern K.C., Nasrallah I.M., Bryan R.N., Reboussin D.M, & Wright C.B. (2023). Intensive Systolic Blood Pressure Treatment Remodels Brain Perivascular Spaces: A Secondary Analysis of SPRINT. medRxiv.

Publication Preprint 2023

Ace inhibitors Angiotensin receptor blockers Antihypertensive Beta blockers Calcium channel blockers Dihydropyridine Diuretics Potassium Thiazide

Corresponding Organization :

Other organizations : National Institute of Neurological Disorders and Stroke, National Institutes of Health, University of Pennsylvania, Wake Forest University

Top 5 similar protocols

Variable analysis

independent variables

Exposure to each class of antihypertensive medications, calculated as the fraction of days taking the antihypertensive from randomization to follow-up MRI

dependent variables

PVS volumes

control variables

Antihypertensive classes were combined as follows: ACE inhibitors and angiotensin receptor blockers, selective and non-selective beta blockers, dihydropyridine and non-dihydropyridine calcium channel blockers, and diuretics including thiazide, loop, and potassium-sparing

Annotations

Based on most similar protocols

Etiam vel ipsum. Morbi facilisis vestibulum nisl. Praesent cursus laoreet felis. Integer adipiscing pretium orci. Nulla facilisi. Quisque posuere bibendum purus. Nulla quam mauris, cursus eget, convallis ac, molestie non, enim. Aliquam congue. Quisque sagittis nonummy sapien. Proin molestie sem vitae urna. Maecenas lorem.

As authors may omit details in methods from publication, our AI will look for missing critical information across the 5 most similar protocols.

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!