Antimicrobial Susceptibility Testing by Broth Microdilution

Antimicrobial susceptibility testing was performed using the broth microdilution method. The antibiotics (Wenzhou Kangtai Biotechnology Company, Wenzhou, China) included ceftazidime (CAZ), cefepime (FEP), ceftazidime/avibactam (CZA), aztreonam (ATM), piperacillin/tazobactam (TZP), nitrofurantoin (NIT), imipenem (IPM), meropenem (MEM), amikacin (AMK), levofloxacin (LVX), tigecycline (TGC), and PB. The minimum inhibitory concentrations (MICs) of the antibiotics, except that of TGC, were in accordance with those defined by the Clinical and Laboratory Standards Institute (CLSI) 2021 breakpoints [44 ]. Susceptibility to TGC was interpreted according to the US Food and Drug Administration (US-FDA) breakpoints (https://www.fda.gov/drugs/development-resources/tigecycline-injection-products). E. coli ATCC 25922 was used for quality control.

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Tang M., Li J., Liu Z., Xia F., Min C., Hu Y., Wang H, & Zou M. (2023). Clonal transmission of polymyxin B-resistant hypervirulent Klebsiella pneumoniae isolates coharboring blaNDM-1 and blaKPC-2 in a tertiary hospital in China. BMC Microbiology, 23, 64.

Publication 2023

Amikacin Antibiotics Antimicrobial Aztreonam Cefepime Ceftazidime Ceftazidime avibactam Clinical laboratory Drugs products E coli Imipenem Kangtai Levofloxacin Meropenem Minimum inhibitory concentrations Nitrofurantoin Piperacillin tazobactam Susceptibility Tigecycline

Corresponding Organization :

Other organizations : Xiangya Hospital Central South University, Central South University

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Variable analysis

independent variables

Ceftazidime (CAZ)
Cefepime (FEP)
Ceftazidime/avibactam (CZA)
Aztreonam (ATM)
Piperacillin/tazobactam (TZP)
Nitrofurantoin (NIT)
Imipenem (IPM)
Meropenem (MEM)
Amikacin (AMK)
Levofloxacin (LVX)
Tigecycline (TGC)

dependent variables

Minimum inhibitory concentrations (MICs) of the antibiotics

control variables

E. coli ATCC 25922 was used for quality control

controls

E. coli ATCC 25922 was used as a positive control

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