Immune Response to ChAdOx1 nCoV-19 Vaccination

ChAdOx1 nCoV-19 cohort: Subjects (age 25–46) visiting ESIC Medical College & Hospital, Faridabad for vaccination were enrolled in the study after obtaining written informed consent. About 4 ml of whole blood was collected for serum preparation four weeks after the first and second dose of vaccination and a follow-up sample was collected after six months. Nasopharyngeal/Oropharyngeal (NP/OP) swabs were collected from patients with symptoms of COVID-19 infection. Total RNA was isolated to detect SARS-CoV-2 using COVIDsure multiplex real-time RT-PCR kit (Trivitron Healthcare) either at Employees State Insurance Corporation (ESIC) Medical College & Hospital or at the bioassay laboratory Translational Health Science and Technology Institute, Faridabad. Clinical presentations were mild to moderate fever, dry cough, and loss of sense of smell and taste. All COVID-19 positive patients were self-isolated and recovered without any need for clinical intervention or hospitalization. A follow-up blood sample was collected after 3–4 weeks post-recovery in both second (May 2021) and third wave (Feb 2022).

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Singh J., Anantharaj A., Panwar A., Rani C., Bhardwaj M., Kumar P., Chattopadhyay P., Devi P., Maurya R., Mishra P., Pandey A.K., Pandey R, & Medigeshi G.R. (2023). BA.1, BA.2 and BA.2.75 variants show comparable replication kinetics, reduced impact on epithelial barrier and elicit cross-neutralizing antibodies. PLOS Pathogens, 19(2), e1011196.

Publication 2023

Bioassay Blood Chadox1 ncov 19 Cough Covid 19 Fever Hospital employees Hospitalization Nasopharyngeal Oropharyngeal Patients Real time pcr Sars cov 2 Second vaccination Serum Taste Vaccination

Corresponding Organization : Translational Health Science and Technology Institute

Other organizations : Academy of Scientific and Innovative Research, Institute of Genomics and Integrative Biology, Employees' State Insurance Model Hospital

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Variable analysis

independent variables

First dose of ChAdOx1 nCoV-19 vaccination
Second dose of ChAdOx1 nCoV-19 vaccination

dependent variables

Serum preparation four weeks after the first dose
Serum preparation four weeks after the second dose
Follow-up serum sample after six months
SARS-CoV-2 detection in NP/OP swabs using COVIDsure multiplex real-time RT-PCR kit
Clinical presentations (mild to moderate fever, dry cough, and loss of sense of smell and taste)
Recovery without clinical intervention or hospitalization
Follow-up blood sample after 3-4 weeks post-recovery

control variables

Age of subjects (25-46 years)
Subjects visiting ESIC Medical College & Hospital, Faridabad for vaccination

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