Dynamic PET Imaging and Kinetic Analysis

Sixty minutes of dynamic PET images were obtained on a Siemens Biograph 40 PET/CT scanner after intravenously injecting 370 ± 18 MBq (10.0 ± 0.5 mCi) of ¹⁸F-FDG. Venous blood samples were obtained throughout the scan as previously described [25 (link), 26 (link)]. A low-dose computed tomography (CT) scan was obtained for attenuation correction of the PET images. All scans were analyzed using Integrated Research Workflow 4.0 (Siemens) as previously described [25 (link), 26 (link), 37 (link)]. Briefly, the baseline and post-endotoxin PET and CT scans were coregistered. Volumes of interest (VOIs) were then placed on the CT images in areas of post-procedure airspace inflammation and transferred to the PET images to extract the time-activity curves. The Patlak graphical analysis was used to calculate the influx constant K_i [38 (link), 39 (link)]. The SUV_mean at 60 min after tracer injection was quantified for ¹⁸F-FDG uptake from the same VOIs used for the Patlak analysis.

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Chen D.L., Huang H.J., Byers D.E., Shifren A., Belikoff B., Engle J.T., Arentson E., Kemp D., Phillips S., Scherrer D.E., Fujiwara H., Spayd K.J., Brooks F.J., Pierce R.A., Castro M, & Isakow W. (2018). The peroxisome proliferator-activated receptor agonist pioglitazone and 5-lipoxygenase inhibitor zileuton have no effect on lung inflammation in healthy volunteers by positron emission tomography in a single-blind placebo-controlled cohort study. PLoS ONE, 13(2), e0191783.

Publication 2018

Biograph 40 Integrated Research Workflow 4.0

18f fdg Computed tomography Computed tomography scanner Endotoxin Inflammation Scans Venous blood

Corresponding Organization : Center for Clinical Studies

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Variable analysis

independent variables

Injection of 370 ± 18 MBq (10.0 ± 0.5 mCi) of ^18F-FDG

dependent variables

Influx constant Ki (calculated using Patlak graphical analysis)
SUVmean at 60 min after tracer injection

control variables

Siemens Biograph 40 PET/CT scanner used for imaging
Low-dose computed tomography (CT) scan obtained for attenuation correction of the PET images
Baseline and post-endotoxin PET and CT scans coregistered
Volumes of interest (VOIs) placed on the CT images in areas of post-procedure airspace inflammation and transferred to the PET images to extract the time-activity curves
Integrated Research Workflow 4.0 (Siemens) used for data analysis, as previously described in references [25], [26], and [37]

controls

Venous blood samples obtained throughout the scan, as previously described in references [25] and [26]

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