Lifestyle Intervention for Fertility Treatment Eligibility
As soon as patients in the intervention arm have finished their six-month lifestyle program, or have met their target weight reduction of 5-10% or when their BMI has decreased below 29 kg/m2 , conventional fertility treatment will be started according to their individual prognosis based on the Hunault model [36 (link)]. If the estimated chance of spontaneous conception in ovulatory women is less than 30% in the forthcoming year, or when the couple has been subfertile for more than 3 years, fertility treatment is offered according to the guidelines of the Dutch Society of Obstetrics and Gynaecology (NVOG). Fertility treatment can either be IUI, IVF or ICSI, whatever is indicated according to the Dutch guidelines. When the Hunault model shows a prognosis of more than 30% pregnancy chance in the forthcoming year and patients are less than three years subfertile, expectant management will be proposed. In case of chronic anovulation, ovulation induction will be started using clomiphene or gonadotropins (Figure 1).
Mutsaerts M.A., Groen H., ter Bogt N.C., Bolster J.H., Land J.A., Bemelmans W.J., Kuchenbecker W.K., Hompes P.G., Macklon N.S., Stolk R.P., van der Veen F., Maas J.W., Klijn N.F., Kaaijk E.M., Oosterhuis G.J., Bouckaert P.X., Schierbeek J.M., van Kasteren Y.M., Nap A.W., Broekmans F.J., Brinkhuis E.A., Koks C.A., Burggraaff J.M., Blankhart A.S., Perquin D.A., Gerards M.H., Mulder R.J., Gondrie E.T., Mol B.W, & Hoek A. (2010). The LIFESTYLE study: costs and effects of a structured lifestyle program in overweight and obese subfertile women to reduce the need for fertility treatment and improve reproductive outcome. A randomised controlled trial. BMC Women's Health, 10, 22.
Other organizations :
University Medical Center Groningen, University of Groningen, National Institute for Public Health and the Environment, Isala, Utrecht University, University of Amsterdam, Academic Medical Center, Maastricht University, Leiden University Medical Center, OLVG, Medisch Spectrum Twente, Atrium Medisch Centrum Parkstad, Deventer Ziekenhuis, Medisch Centrum Alkmaar, Rijnstate Hospital, Meander Medisch Centrum, Máxima Medisch Centrum, Radboud University Nijmegen, Treant Zorggroep, St. Antonius Ziekenhuis, Medisch Centrum Leeuwarden, Martini Ziekenhuis, Laurentius Ziekenhuis
Chance of spontaneous conception (< 30% in the forthcoming year)
Subfertility duration (> 3 years)
Prognosis based on the Hunault model (> 30% pregnancy chance in the forthcoming year)
control variables
Not explicitly mentioned
positive controls
Not explicitly mentioned
negative controls
Not explicitly mentioned
Annotations
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