Quantifying White Matter Integrity via DTI

Fractional anisotropy (FA) is one of the most sensitive DTI parameter for detecting the integrity of white matter fibers after cerebral damage [31 (link)]. DTI was acquired using an axial single-shot spin echo-planar sequence with a TR/TE = 6300/25 ms, 30 diffusion encoding directions, two b values = 0 and 1000 s/mm². FA images were reconstructed with paravision version 5.1 software (Bruker, Pharmascan, Germany). FA was measured in the following four regions: ipsilateral cortex and striatum, contralateral cortex and striatum. The relative FA (rFA) was calculated by comparing the parameters in the lesion ROIs (Regions of interest) with the mirrored ROIs of the contralateral side [32 (link)].

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Zhang J., Zou H., Zhang Q., Wang L., Lei J., Wang Y., Ouyang J., Zhang Y, & Zhao H. (2016). Effects of Xiaoshuan enteric-coated capsule on neurovascular functions assessed by quantitative multiparametric MRI in a rat model of permanent cerebral ischemia. BMC Complementary and Alternative Medicine, 16, 198.

Publication 2016

paravision version 5.1 software

Anisotropy Cerebral damage Cortex Diffusion Echo Striatum White matter

Corresponding Organization : Hong Kong Baptist University

Other organizations : Capital Medical University

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Variable analysis

independent variables

Cerebral damage

dependent variables

Fractional anisotropy (FA) in the ipsilateral cortex and striatum
Fractional anisotropy (FA) in the contralateral cortex and striatum
Relative fractional anisotropy (rFA)

control variables

TR/TE = 6300/25 ms
30 diffusion encoding directions
Two b values = 0 and 1000 s/mm^2
Paravision version 5.1 software (Bruker, Pharmascan, Germany) used for FA image reconstruction

positive controls

Mirrored ROIs of the contralateral side used as a control for calculating relative fractional anisotropy (rFA)

negative controls

No negative controls were explicitly mentioned.

Annotations

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