Images were acquired at each study site, and then transferred to Albert Einstein College of Medicine (Bronx, NY) for centralized/harmonized processing. Images were acquired with a Philips 3T MRI scanner (Achieva Quasar TX; Philips Medical Systems, Best, Netherlands) in CCMA, a General Electric (GE) 1.5 T MRI scanner (GE LX Horizon, Milwaukee, WI) in TASCOG, a Siemens 1.5T MRI scanner (Magnetom Avanto; Siemens Medical Solutions, Erlangen, Germany) in GAIT, and a Siemens 3T MRI scanner (TIM Trio, Siemens, Germany) in NCGG-SGS. Standard three-dimensional T1-weighted images were obtained from all cohorts: 1) CCMA: TR/TE of 9.9/4.6 ms, 240 mm2 FOV, and 1 mm voxel size (for additional details, see [41 (link)]), 2) TASCOG: TR/TE of 37/7 ms, 240 mm2 FOV, and 1 mm voxel size [42 (link)], 3) GAIT: TR/TE 2170/4.07 ms, 240 mm2 mm FOV, and 1 mm voxel size [26 (link)], and 4) NCGG-SGS: TR/TE of 1.98/1800 ms and 1.1 mm voxel size [45 (link)].