Mice were sensitized on alternate days by administration of OVA (500 μL, 5%, IP) till day 14. 29 (link) Sensitized mice were randomly divided (n = 18 mice/group) into various groups AR control (received distilled water [DW; 10 mg/kg, PO]), montelukast (10 mg/kg, PO), 30, (link)31 and galangin (5, 10, and 20 mg/kg, PO) 32 (link) and received respective treatments till day 21. The normal group of mice received aluminum hydroxide IP without OVA and was treated with DW (10 mg/kg), whereas the per se group received galangin (20 mg/kg) only till day 21. On day 21, nasal symptoms were evaluated using a method reported elsewhere. 29 (link) The solutions of galangin were freshly prepared daily by dissolving in DW (1 mg/ml) and administered orally for biological evaluations.
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Galangin Mitigates Allergic Rhinitis
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independent variables
- Administration of OVA (500 μL, 5%, IP) on alternate days till day 14
- Treatment with distilled water (DW; 10 mg/kg, PO), montelukast (10 mg/kg, PO), and galangin (5, 10, and 20 mg/kg, PO) till day 21
- Nasal symptoms evaluated on day 21
- Normal group of mice received aluminum hydroxide IP without OVA and was treated with DW (10 mg/kg)
- Per se group received galangin (20 mg/kg) only till day 21
- Positive control: Normal group of mice received aluminum hydroxide IP without OVA and was treated with DW (10 mg/kg)
- Negative control: Per se group received galangin (20 mg/kg) only till day 21
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