SBRT for Unidentified Lesions via VMAT/IMRT

Patients underwent CT simulation in a supine position with a slide of 2.5 mm. All patients were immobilized using a vacuum-assisted body mold to recreate exact positioning during daily sessions. Target lesion was not readily identified on the CT simulation, and the planning data set was registered to a diagnostic contrast CT or PET-CT, using a mutual information algorithm from our in-house treatment system, to facilitate gross tumor volume (GTV) delineation. A 3–8 mm isotropic expansion was generated from GTV to obtain planning target volume (PTV). Organs at risk (OARs) were delineated depending on the target lesion location without margins. The treatment planning system was Eclipse 4.5.5 (Varian), and VMAT/IMRT technique on a 6-MV linear accelerator Varian were used for treatment. The dose of SBRT was converted to the biologically effective dose (BED) to compare different dose-fractionation schedules. The BED was calculated using the linear-quadratic model with α/β = 10 Gy for the tumor and α/β = 3 to the organs at risk. Dose schedules were chosen with the aim of delivering ablative treatments respecting dose constraints for OARs.

Free full text: Click here

Facondo G., Vullo G., De Sanctis V., Rotondi M., Sigillo R.C., Valeriani M, & Osti M.F. (2023). Clinical Outcomes of Stereotactic Body Radiotherapy (SBRT) for Oligometastatic Patients with Lymph Node Metastases from Gynecological Cancers. Journal of Personalized Medicine, 13(2), 229.

Publication 2023

Eclipse 4.5.5 6-MV linear accelerator

Body Diagnostic Dose fractionation Imrt Linear accelerator Mold Organs at risk Patients Pet ct Tumor Vacuum Vmat

Corresponding Organization : Sapienza University of Rome

Top 5 similar protocols

Variable analysis

independent variables

Dose-fractionation schedules

dependent variables

Biologically effective dose (BED)
Dose constraints for organs at risk (OARs)

control variables

CT simulation in supine position with a slice thickness of 2.5 mm
Immobilization using a vacuum-assisted body mold to recreate exact positioning during daily sessions
Registration of planning data set to a diagnostic contrast CT or PET-CT using a mutual information algorithm
3–8 mm isotropic expansion from GTV to obtain planning target volume (PTV)
Delineation of organs at risk (OARs) without margins depending on the target lesion location
Use of Eclipse 4.5.5 (Varian) treatment planning system
Use of VMAT/IMRT technique on a 6-MV linear accelerator Varian

Annotations

Based on most similar protocols

Etiam vel ipsum. Morbi facilisis vestibulum nisl. Praesent cursus laoreet felis. Integer adipiscing pretium orci. Nulla facilisi. Quisque posuere bibendum purus. Nulla quam mauris, cursus eget, convallis ac, molestie non, enim. Aliquam congue. Quisque sagittis nonummy sapien. Proin molestie sem vitae urna. Maecenas lorem.

As authors may omit details in methods from publication, our AI will look for missing critical information across the 5 most similar protocols.

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!