Blood was obtained fasting at entry, month 4, and month 24 for assessment of lipids (LDL and non–high-density lipoprotein cholesterol), inflammatory (high-sensitivity C-reactive protein [hsCRP], lipoprotein-associated phospholipase A2 [LpPLA2], and oxidized low-density lipoprotein [oxLDL]), and immune activation biomarkers (monocyte chemoattractant protein 1, IL-6, IL-10, IL-1β, IL-18, soluble CD14, and soluble CD163). Lipids and hsCRP were measured from serum at Quest Diagnostics, Secaucus, New Jersey. Inflammatory and immune biomarkers were measured from plasma using enzyme-linked immunosorbent assay kits (R&D Systems) except for oxLDL (Mercodia) at Temple University, Philadelphia, Pennsylvania.
Other organizations :
Cancer Research And Biostatistics, University of Applied Sciences Stralsund, Semmelweis University, University Medical Center Freiburg, University of Freiburg, Temple University, Alaska Heart and Vascular Institute, The Ohio State University Wexner Medical Center, Frontier Science & Technology Research Foundation, Duke University, Clinical Research Institute, National Institute of Allergy and Infectious Diseases, National Institutes of Health, National Heart Lung and Blood Institute, University of Alabama at Birmingham, University of California, Los Angeles, Icahn School of Medicine at Mount Sinai, University of Cincinnati Medical Center
Lipids (LDL and non–high-density lipoprotein cholesterol)
Inflammatory biomarkers (high-sensitivity C-reactive protein [hsCRP], lipoprotein-associated phospholipase A2 [LpPLA2], and oxidized low-density lipoprotein [oxLDL])
Immune activation biomarkers (monocyte chemoattractant protein 1, IL-6, IL-10, IL-1β, IL-18, soluble CD14, and soluble CD163)
control variables
None explicitly mentioned
controls
Positive control: None mentioned
Negative control: None mentioned
Annotations
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