The pharmacokinetic profile of tiamulin was investigated utilizing the non-compartmental approach [WinNonlin 8.3 software (Certara, USA)] as reported (15 (link), 16 (link)). The values of the highest plasma concentration (Cmax) and the time required to attain Cmax (Tmax) were recorded from the plasma concentration-time plot. The area under the plasma concentration-time curve (AUC0−∞) was computed using the linear-log trapezoidal method. The elimination half-life (T1/2λz) was calculated using the equation T1/2λz = 0.693/λz.
The withdrawal time (WT) was calculated by applying WT 1.4 program which was established in Germany and approved by the CVMP of the EU. It was estimated utilizing the statistical approach (95% tolerance limit and 95% confidence interval) based on the EU MRL for tiamulin in chicken tissues, which were announced by the CVMP to be 0.1 μg/g for muscles, skin, and fat, and 1 μg/g for liver, respectively (24 ).
The withdrawal time (WT) was calculated by applying WT 1.4 program which was established in Germany and approved by the CVMP of the EU. It was estimated utilizing the statistical approach (95% tolerance limit and 95% confidence interval) based on the EU MRL for tiamulin in chicken tissues, which were announced by the CVMP to be 0.1 μg/g for muscles, skin, and fat, and 1 μg/g for liver, respectively (24 ).
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