Integrating Diverse Biological Networks
Corresponding Organization : Yale University
Other organizations : Harvard University, Dana-Farber Cancer Institute
Protocol cited in 53 other protocols
Variable analysis
- Different datasets (e.g., the FYI [Vidal et al.] or the DIP core [Eisenberg et al.])
- Removing the ribosome and the proteasome complexes
- Interaction data gathered from published high-throughput datasets and published databases
- Regulatory network created by combining five different datasets
- Essential genes in yeast genome determined experimentally
- Metabolic network taken from the Kyoto Encyclopedia of Genes and Genomes (KEGG)
- Genetic network data downloaded from the GRID
- Expression data taken from the Rosetta compendium expression dataset
- Independent genomic features and Bayesian integration used to eliminate noise from the dataset
- DNA-binding enzymes (e.g., PolIII) excluded from the regulatory network
- Figures S1 and S4A showing the same behavior in different datasets
- Figures S2 and S4B showing the results after removing the ribosome and the proteasome complexes
- None explicitly mentioned
Annotations
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