Ketoconazole and bicalutamide (i.e., casodex) were obtained from LKT Laboratories Inc. (St Paul, MN). Unlabeled tasquinimod and 14C-tasquinimod labeled in the 3 position of the quinoline nucleus at a specific activity of 33.9 mCi/mmol (> 90% purity) were provided by Active Biotech Inc. AB. Tasquinimod metabolites were prepared at Active Biotech AB (Lund, Sweden) as previously described [7 (link), 12 (link)].
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