Basic data and primary and secondary endpoints were collected for both groups by reviewing medical records. The basic data collected included gender, birth weight, gestational age. The primary endpoints were PaO2, carbon dioxide partial pressure (PaCO2) and oxygenation index (OI) 12 and 24 hours after the start of NIV. The incidences of intraventricular hemorrhage (IVH) or periventricular leukomalacia (PVL), necrotizing enterocolitis (NEC), bronchopulmonary dysplasia (BPD), and apnea during the first 72 hours were the secondary endpoints. In addition, the treatment effects including duration of NIV, duration of nasal cannula oxygen therapy, length of hospital stay, time to full feeding and maternal high-risk factors related to the parturients, the use rates of antenatal corticosteroid and surfactant and delivery mode were compared between groups.
Protocol detail
Noninvasive Ventilation Outcomes in Preterm Infants
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Apnea
Birth weight
Bronchopulmonary dysplasia
Carbon dioxide
Corticosteroid
Delivery
Gestational age
Hemorrhage
Maternal
Nasal cannula
Necrotizing enterocolitis
Oxygen
Oxygenation
Partial pressure
Periventricular leukomalacia
Surfactant
Corresponding Organization :
Other organizations : Huaibei Normal University, Weatherford College
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Variable analysis
independent variables
- None explicitly mentioned
- PaO2 (partial pressure of oxygen)
- PaCO2 (partial pressure of carbon dioxide)
- Oxygenation Index (OI)
- Incidence of intraventricular hemorrhage (IVH) or periventricular leukomalacia (PVL)
- Incidence of necrotizing enterocolitis (NEC)
- Incidence of bronchopulmonary dysplasia (BPD)
- Incidence of apnea during the first 72 hours
- Duration of non-invasive ventilation (NIV)
- Duration of nasal cannula oxygen therapy
- Length of hospital stay
- Time to full feeding
- Gender
- Birth weight
- Gestational age
- Maternal high-risk factors
- Use rates of antenatal corticosteroid
- Use rates of surfactant
- Delivery mode
- None explicitly mentioned
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