The endpoint was defined as the day on which the righting reflex disappeared. Transgenic rats used in the experiments were numbered in birth order. Rats treated with full-length antibodies, D3-1, and PBS were selected numerically and alternately. Rats treated with OPCs were selected numerically in the following order: OPC scFv, OPC GFP, and medium. All functional measurements were performed by a person blinded to the treatment. The methods used were as follows.
Minamiyama S., Sakai M., Yamaguchi Y., Kusui M., Wada H., Hikiami R., Tamaki Y., Asada-Utsugi M., Shodai A., Makino A., Fujiwara N., Ayaki T., Maki T., Warita H., Aoki M., Tomonaga K., Takahashi R, & Urushitani M. (2023). Efficacy of oligodendrocyte precursor cells as delivery vehicles for single-chain variable fragment to misfolded SOD1 in ALS rat model. Molecular Therapy. Methods & Clinical Development, 28, 312-329.
Treatment type: full-length antibodies, D3-1, PBS, OPC scFv, OPC GFP, and medium
dependent variables
Time until the righting reflex disappeared
control variables
Transgenic rats were numbered in birth order
Rats treated with full-length antibodies, D3-1, and PBS were selected numerically and alternately
Rats treated with OPCs were selected numerically in the following order: OPC scFv, OPC GFP, and medium
All functional measurements were performed by a person blinded to the treatment
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