11C-acetate PET Imaging of Cardiac Metabolism

A total of 400 MBq 11C-acetate was injected, followed by list-mode PET recording for 27 minutes on a Biograph TruePoint TrueV 64 PET/computed tomography scanner (Siemens, Germany). Blood pressure and HR were measured at 1, 5, 10, and 20 minutes after injection. The examination was performed to obtain the global clearance rate (k₂) and to calculate MVO₂ as previously described:^{11 (link)}Dynamic data sets were analyzed to estimate SV by use of aQuant Research.^{12 (link)} HR and MAP were measured noninvasively. Left ventricular mass and CO were obtained from the PET dataset, and MEE was calculated as:^{13 (link)}MBF (mL · g^-1 · min^-1) was estimated by measuring k₁ and correcting for rate pressure product as previously described.^{14 (link)} The assessor of the PET examinations was blinded to treatment allocation and group.

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Nielsen R., Møller N., Gormsen L.C., Tolbod L.P., Hansson N.H., Sorensen J., Harms H.J., Frøkiær J., Eiskjaer H., Jespersen N.R., Mellemkjaer S., Lassen T.R., Pryds K., Bøtker H.E, & Wiggers H. (2019). Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients. Circulation, 139(18), 2129-2141.

Publication 2019

Biograph TruePoint TrueV 64

11c acetate Blood pressure Clearance rate Computed tomography scanner Examinations Left ventricular Pressure

Corresponding Organization :

Other organizations : Aarhus University Hospital, Aarhus University, Uppsala University

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

Global clearance rate (k2)
Myocardial oxygen consumption (MVO2)
Stroke volume (SV)
Heart rate (HR)
Mean arterial pressure (MAP)
Left ventricular mass
Cardiac output (CO)
Myocardial efficiency (MEE)
Myocardial blood flow (MBF)

control variables

Examination was performed on a Biograph TruePoint TrueV 64 PET/computed tomography scanner (Siemens, Germany)
Blood pressure and HR were measured at 1, 5, 10, and 20 minutes after injection
The assessor of the PET examinations was blinded to treatment allocation and group

positive controls

None explicitly mentioned

negative controls

None explicitly mentioned

Annotations

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