Protocol detail

Quantitative Femoral Bone Microstructure

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Micro-computed tomography (μCT) was performed on distal femurs with the Skyscan 1172 system (Bruker), as described previously.^{19 (link)} 3D models of bones were generated using CTVol software (Bruker). The number of cortical perforations > 50 μm in diameter was counted blinded on reconstructed images.

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Muller J., Bolomsky A., Dubois S., Duray E., Stangelberger K., Plougonven E., Lejeune M., Léonard A., Marty C., Hempel U., Baron F., Beguin Y., Cohen-Solal M., Ludwig H., Heusschen R, & Caers J. (2018). Maternal embryonic leucine zipper kinase inhibitor OTSSP167 has preclinical activity in multiple myeloma bone disease. Haematologica, 103(8), 1359-1368.

Publication 2018

Skyscan 1172 system CTVol software

Bones Computed tomography Cortical Femurs

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Variable analysis

independent variables

Micro-computed tomography (μCT) performed on distal femurs

dependent variables

Number of cortical perforations > 50 μm in diameter

control variables

Distal femurs

controls

Positive control: Not specified
Negative control: Not specified

Annotations

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