Diarrhea was defined as unformed stools ≥ 3 times per day on two consecutive days, and CDI was confirmed when toxigenic culture was positive in diarrheal patients, or the toxin assay A&B (VIDAS®C. difficile Toxin A & B; BioMerieux SA, Marcy l’Etoile, France) yielded positive results, and/or pseudomembranes were seen by endoscopy or histology [10 (link)]. Healthcare-associated CDI (HA-CDI) was diagnosed in patients who developed diarrhea at least 72 hour after hospitalization or within two months of their last discharge from hospital [15 (link)].
Clinical cure was defined as resolution of diarrhea within the treatment period. This required conversion to no more than two semi-formed or formed stools per day [15 (link)]. Recurrence was defined as growth of C. difficile with toxin genes, positive toxin assay A&B, or pseudomembranes, with recurrence of symptoms between the end of treatment and 30 days later.
Clinical cure was defined as resolution of diarrhea within the treatment period. This required conversion to no more than two semi-formed or formed stools per day [15 (link)]. Recurrence was defined as growth of C. difficile with toxin genes, positive toxin assay A&B, or pseudomembranes, with recurrence of symptoms between the end of treatment and 30 days later.
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