Genotype data was generated using Illumina HumanHap550 BeadChip (Illumina Inc., San Diego, CA, USA). Quality control was performed including the removal of SNPs with minor allele frequencies below 1%, and those not in Hardy-Weinberg equilibrium (p < 1 × 10−5), as described previously [42 (link)]. Multi-dimensional Scaling (MDS) in PLINK [43 (link)] was used to construct three population covariates (PCs), which were used in all analyses to correct for minor differences related to ancestry.
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Genotype Data Quality Control
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Other organizations : King's College London, City, University of London
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Variable analysis
independent variables
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- Population covariates (PCs) derived from Multi-dimensional Scaling (MDS) analysis in PLINK, used to correct for minor differences related to ancestry
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