Evaluating PMT-NC and Sly Vaccine Efficacy

Twelve healthy piglets without P. multocida antibodies were divided into three groups (n = 4 each). The vaccinated groups were immunized intramuscularly with 2 mL of (4) rPMT-NC + w/o/w + rSly (100 μg/mL), (5) rPMT-NC + w/o/w + rSly (150 μg/mL), or (6) PBS as a negative control (Table 1). The antibody titre was determined for blood samples taken at 0, 2 and 4 weeks after primary immunization. CD4⁺ and CD8⁺ T-cell analysis was performed at week 4.

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Wu M.C., Wu H.C., Lee J.W., Chang W.C, & Chu C.Y. (2023). A protein-based subunit vaccine with biological adjuvants provides effective protection against Pasteurella multocida in pigs. Veterinary Research, 54, 17.

Publication 2023

Antibodies Antibody Blood Cd8 t cell Immunization P multocida

Corresponding Organization :

Other organizations : National Pingtung University of Science and Technology

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Variable analysis

independent variables

RPMT-NC + w/o/w + rSly (100 μg/mL)
RPMT-NC + w/o/w + rSly (150 μg/mL)
PBS as a negative control

dependent variables

Antibody titre (determined for blood samples taken at 0, 2 and 4 weeks after primary immunization)
CD4+ and CD8+ T-cell analysis (performed at week 4)

control variables

Twelve healthy piglets without P. multocida antibodies

negative control

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