PET emission data were acquired on a Siemens ECAT HR+PET scanners as previously described [35 (link)]. Briefly, participants were positioned in the scanner approximately 35 min after [11C]PiB injection (15 mCi). A 10 min transmission scan was acquired using rotating 68Ge/68Ga rod sources to correct for photon attenuation, followed by a 20 min emission scan (4 × 5 min frames) beginning 50 min after [11C]PiB injection. PET emission data were reconstructed using filtered back-projection (Direct Inverse FourierTransform) into a 128 × 128 × 63 matrix with voxel sizes of 2.06 × 2.06 × 2.43 mm3. Images were filtered with a 3mm Hann window.
Protocol detail
PET Imaging of Amyloid Deposition
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Frames
Scan
Transmission
Corresponding Organization : University of Pittsburgh
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Variable analysis
independent variables
- Time after [11C]PiB injection (approximately 35 min)
- PET emission data
- Participants' positioning in the Siemens ECAT HR+PET scanner
- Transmission scan using rotating 68Ge/68Ga rod sources
- Emission scan duration (20 min, 4 × 5 min frames)
- PET data reconstruction (128 × 128 × 63 matrix, 2.06 × 2.06 × 2.43 mm3 voxel size, 3mm Hann window filtering)
- Positive control: None specified
- Negative control: None specified
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