Quantifying Amyloid Burden with [18F]Florbetapir PET

[18 F]Florbetapir PET data were quantified using the standardized uptake value ratio (SUVr), with the cerebellum grey matter serving as the reference region. The global cortical Aβ burden was computed as the mean SUVr in cortical area, including posterior cingulate, precuneus, frontal, lateral parietal, lateral temporal, medial temporal, and occipital regions. The positive 18F-florbetapir PET images were defined through visual rating following the guidelines for interpreting amyloid PET^{42 (link)}. Three physicians independently assessed all amyloid PET images, and results were determined based on a consensus, with agreement among at least two physicians. Additional details on the acquisition and preprocessing of [18 F]Florbetapir PET neuroimaging are provided in the supplementary information.

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Chen T., Pan F., Huang Q., Xie G., Chao X., Wu L., Wang J., Cui L., Sun T., Li M., Wang Y., Guan Y., Zheng X., Ren Z., Guo Y., Wang L., Zhou K., Zhao A., Guo Q., Xie F, & Jia W. (2024). Metabolic phenotyping reveals an emerging role of ammonia abnormality in Alzheimer’s disease. Nature Communications, 15, 3796.

Publication 2024

Corresponding Organization :

Other organizations : Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Huashan Hospital, Fudan University, University of Hong Kong

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

Global cortical Aβ burden computed as the mean SUVr in cortical areas
Amyloid PET image positivity defined through visual rating

control variables

Cerebellum grey matter used as the reference region for SUVr quantification

controls

Positive control: Not explicitly mentioned
Negative control: Not explicitly mentioned

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