Sericin-enhanced Bone Graft Materials

Yeonnokjam was prepared by the Sericultural and Apicultural Division, National Institute of Agricultural Science, Rural Development Administration (RDA). The sericin from Yeonnokjam was treated by 4-hexylresorcinol (4HR) before degumming process to improve its protein conformation [16 (link)]. Gelatin sponge (Cutanplast Dental®, Uniplex, Sheffield, UK) with Yeonnokjam sericin (group G) and collagen membrane (Geistlich Bio-Gide®, Geistlich Pharma AG, Switzerland) with Yeonnokjam sericin (group C) were used as graft materials. All prepared grafts were fragmented for implanting into the bony defect. The detailed sample preparation procedure was shown in Fig. 1. Each graft contained approximately 50 μg of sericin.Fig. 1

Schematic drawings of experimental procedure