Investigating ULK1 Expression in Liver Cancer

A gene expression profile of 424 LIHC (liver hepatocellular carcinoma) patients was downloaded from UCSC Xena datahub (

https://gdc-hub.s3.us-east-1.amazonaws.com/download/TCGA-LIHC.htseq_fpkm.tsv.gz

). Then, normalized mRNA expression of ULK1 in liver cancer and normal liver tissues was analyzed by GraphPad Prism 7.0 (GraphPad Prism Software, La Jolla, CA). Comparison of ULK1 expression among cancer cell lines was performed using the online tool Cancer Cell Line Encyclopedia (

https://sites.broadinstitute.org/ccle/

). Tumor tissues from patients diagnosed with HCC accompanied by hepatitis B virus infection and paired adjacent non-tumor tissues were used to detect ULK1 protein expression in liver cancer.

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Duan T., Yang X., Kuang J., Sun W., Li J., Ge J., Zhang M., Cai X., Yu P., Yang J, & Zhu X. (2023). ULK1 Depletion Protects Mice from Diethylnitrosamine-Induced Hepatocarcinogenesis by Promoting Apoptosis and Inhibiting Autophagy. Journal of Hepatocellular Carcinoma, 10, 315-325.

Publication 2023

Cancer Cell line Hepatitis b virus infection Liver Liver cancer Mrna Patients Prism Tissues Tumor Ulk1 Ulk1 protein

Corresponding Organization :

Other organizations : Hangzhou Normal University, Zhejiang University, National University of Defense Technology, Fourth Affiliated Hospital of China Medical University

Top 5 similar protocols

Variable analysis

independent variables

ULK1 mRNA expression

dependent variables

ULK1 protein expression
Comparison of ULK1 expression among cancer cell lines

control variables

Tumor tissues from patients diagnosed with HCC accompanied by hepatitis B virus infection
Paired adjacent non-tumor tissues

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