The following endpoints were defined: in-hospital death (endpoint 1), the need for KRT (endpoint 2), and recovery of kidney function until discharge (endpoint 3). The need for KRT was fulfilled if a patient required at least one extracorporal procedure. Extracorporal therapy was initiated, if patients presented one or more of the following criteria: refractory hyperhydration including progressive dyspnea, refractory hyperkalemia of 6.5 mmol/L or above, refractory metabolic acidosis with a pH of 7.1 or below, neurological symptoms due to suspected uremia. KRT was either performed as intermittent hemodialysis, or slow extended daily dialysis (SLEDD), or continuous veno-venous hemodialysis. Recovery of kidney function was diagnosed if the last eGFR (CKD-EPI [12 (link)]) differed from the initial eGFR by no more than 10%. Data on endpoints 1 and 2 were available from all patients, and data on endpoint 3 were missing in 50 subjects.
Protocol detail
Endpoints for Acute Kidney Injury
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Continuous veno venous hemodialysis
Discharge
Dyspnea
Egfr
Extended daily dialysis
Hemodialysis
Hyperhydration
Kidney
Metabolic acidosis
Neurological symptoms
Patients
Recovery of function
Therapy
Uremia
Corresponding Organization :
Other organizations : Klinikum Brandenburg
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Variable analysis
independent variables
- No independent variables explicitly mentioned.
- In-hospital death (endpoint 1)
- The need for KRT (endpoint 2)
- Recovery of kidney function until discharge (endpoint 3)
- No control variables explicitly mentioned.
- The input protocol describes the endpoints that were defined for the study, but does not mention any independent variables that were manipulated by the researchers. The dependent variables are the three endpoints that were measured: in-hospital death, the need for kidney replacement therapy (KRT), and recovery of kidney function until discharge. The input does not specify any control variables that were kept constant to ensure valid results.
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