All individuals were administered 111 MBq (±10%) [123I]mIBG via slow intravenous injection. Potassium iodate tablets (170 mg) were given before and after injection to minimise uptake of free iodine by the thyroid. Ten-minute anterior planar images were acquired at 20 min (early) and at 4 h (± 30 min) after injection (delayed). All images were acquired on a dual-headed Siemens Symbia Intevo or Siemens Symbia gamma camera (Siemens Healthcare, Munich, Germany) with medium energy low penetration (MELP) collimators with an energy window of 159 keV ± 10%, matrix size 128 × 128 and no zoom applied [3 (link),13 (link)].
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Cardiac [123I]mIBG Imaging Protocol
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Corresponding Organization : Newcastle upon Tyne Hospitals NHS Foundation Trust
Other organizations : Queen's University Belfast, University of Cambridge
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Variable analysis
independent variables
- Administration of 111 MBq (±10%) [123I]mIBG via slow intravenous injection
- Ten-minute anterior planar images acquired at 20 min (early) and at 4 h (± 30 min) after injection (delayed)
- Administration of potassium iodate tablets (170 mg) before and after injection to minimize uptake of free iodine by the thyroid
- Imaging performed on a dual-headed Siemens Symbia Intevo or Siemens Symbia gamma camera with medium energy low penetration (MELP) collimators, energy window of 159 keV ± 10%, matrix size 128 × 128 and no zoom applied
- Potassium iodate tablets (170 mg) administered before and after injection to minimize uptake of free iodine by the thyroid (positive control)
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