Hemodynamic and Barrier Dynamics in Hypertensive Rats

Data are presented as means ± SEM and submitted to Shapiro-Wilk homogeneity variance test. Treadmill performance and body weight in S and T SHR and Wistar rats were analyzed by three-way ANOVA with repeated measurements (time). Differences in hemodynamic and autonomic parameters, BBB permeability, ultrastructural changes in BBB constituents, and caveolin-1 expression between groups and conditions were analyzed by two-way factorial ANOVA. Tukey was the post hoc test. Correlations analyses used the Pearson statistics. All statistical analyses were performed by the GraphPad Prism 8 software. Differences were considered significant at p < 0.05.