All the patients included in the study will undergo LC with intraoperative NIRFC through intravenous administration of ICG (Verdye (Diagnostic Green GMBH, Achheim-Dornach, Germany)). The administration protocols of this drug will be divided according to the dose and time interval until surgery, as detailed below (figure 1):
Surgery will be conducted based on the criteria for safe LC. The surgeons who will perform this technique have wide experience in the treatment of symptomatic gallstone disease and hepatobiliary disorders. Different imaging systems will be used according to each hospital: 1688 Advanced Imaging Modalities (AIM) 4K Platform (Stryker), IMAGE1 S 4U-LINK/RUBINA, OPAL1 NIR/ICG (Karl Storz-Endoskope) and VISERA ELITE II OTV-S300 (Olympus).