A biventricular test loop created HF scenarios utilizing dual pneumatic pumps (Abiomed AB5000™, Danvers, MA, USA) controlled by a double output driver. Inflows for one CFTAH (Figures 3A, B ) and two UVADs (Figures 4A, B ) were configured for both atrial and ventricular cannulations (15 (link)). Assessing BVADs occurred on a static test loop, which resulted in the generation of pressure-flow curves from several pump speeds. For each trial, the BVAD was operated over its entire range (i.e., device-specific motor speeds, aortic pressure ranging from 20 to 120 mm Hg), data was recorded, and pressure differentials were monitored and measured throughout the device.
In our feasibility study, the cannula had a longer length and smaller diameter, which resulted in an increase in flow resistance, requiring the pump to be operated at higher speeds than are typically used in a clinical setting. Ventricular cannulation was verified by measuring device inlet pressures with cannulae clamped proximally. Via fluid-filled pressure lines, hemodynamic data were recorded from both outflow cannulae. From fixed points on the outflow cannulae, near both pump outlets, total cardiac output was recorded.
In our feasibility study, the cannula had a longer length and smaller diameter, which resulted in an increase in flow resistance, requiring the pump to be operated at higher speeds than are typically used in a clinical setting. Ventricular cannulation was verified by measuring device inlet pressures with cannulae clamped proximally. Via fluid-filled pressure lines, hemodynamic data were recorded from both outflow cannulae. From fixed points on the outflow cannulae, near both pump outlets, total cardiac output was recorded.
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