Hydrocortisone Formulations: Concentration Equivalency

Example 4

Equivalent to:Equivalent to:Equivalent to:Equivalent to:

Formulation:50 mg/ml100 mg/ml100 mg/ml100 mg/ml

Componenthydrocortisonehydrocortisonehydrocortisonehydrocortisone

Hydrocortisone67.1 mg6.71%134.2 mg13.42%6710.0 mg13.42%2,013.0 g13.42%

sodium phosphate

Monobasic sodium1.0 mg0.10%1.0 mg0.10%50.0 mg0.10%19.5 g⁽¹⁾ 0.13%⁽¹⁾

phosphate

Dibasic sodium10.9 mg1.09%10.9 mg1.09%545.0 mg1.09%205.5 g ⁽²⁾ 1.37% ⁽²⁾

phosphate

Disodium EDTA0.2 mg0.02%0.2 mg0.02%10.0 mg0.02%3.0 g0.02%

Monothioglycerol5.0 mg0.50%5.0 mg0.50%250.0 mg0.50%75.0 g0.50%

Sodium hydroxide

Water (Q. S.)1 mL1 mL50 mL15,900.0 g ⁽³⁾

⁽¹⁾Monobasic sodium phosphate dihydrate

⁽²⁾Dibasic sodium phosphate dihydrate

⁽³⁾Equivalent to 15 Liter

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US11857555B2. Aqueous pharmaceutical formulation of hydrocortisone sodium phosphate and monothioglycerol (2024-01-02). ANTARES PHARMA, INC. [US]. Inventors: Xiaoming Chen [US], Shaowei Ong [US].

Patent 2024

Dibasic sodium phosphate Disodium edta Hydrocortisone sodium phosphate Hydroxide Monobasic sodium phosphate Monothioglycerol Phosphate Phosphate sodium Sodium hydroxide

Top 5 similar protocols

Variable analysis

independent variables

Formulation

dependent variables

Hydrocortisone
Monobasic sodium phosphate
Dibasic sodium phosphate
Disodium EDTA
Monothioglycerol
Water

control variables

Hydrocortisone
Monobasic sodium phosphate
Dibasic sodium phosphate
Disodium EDTA
Monothioglycerol

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