Tetrahydrofuran (THF), anhydrous sodium sulfate (Na2SO4), N,N-Dimethylformamide (DMF), copper nitrate trihydrate (Cu(NO3)2·3H2O), and p-phthalic acid (H2BDC) were procured from Aladdin (Shanghai, China). Tetrabutylammonium fluoride (TBAF) was purchased from Beijing InnoChem Science and Technology Co., Ltd. Polyvinylpyrrolidone (PVP) and doxorubicin hydrochloride (DOX) were procured from Shanghai Yuanye Biotechnology Co., Ltd. Roswell Park Memorial Institute (RPMI) 1640 medium, fetal bovine serum (FBS), penicillin-streptomycin and phosphate-buffered saline (PBS) were purchased from Gibco (USA). The cell counting Kit-8 (CCK-8) was obtained from Meilunbio (Dalian, China). The ROS assay kit was procured from Beyotime Biotechnology (Shanghai, China). Unless otherwise stated, all the solvents and chemicals were purchased commercially and used without further purification.