The experimental animals were Kunming mice (weighting 22–25 g, half male and female) provided by the Laboratory Animal Centre, Guangzhou University of Chinese Medicine, Guangzhou, China (approval number: 44007200079662). Mice were cared under the standard laboratory conditions, which is temperature 22°C ± 2°C, humidity 50% ± 10%, and 12 h dark-light cycle. And they were allowed to freely consume sterilized water and standard chow. All experimental procedures were approved by the Animal Ethics Committee of Guangzhou University of Chinese Medicine.
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