MR images were obtained using a Siemens 3.0 T MRI system (Siemens Verio, Erlangen, Germany), with a standard head coil. T1 and T2 images were taken with a self-spin echo sequence, and DTI images were taken with a planar echo sequence. The DTI scan consisted of 21 diffusion-weighted directions with a b-value of 1000 s/mm2 and one volume without diffusion weighting (i.e., b0 image). The parameters of the DTI sequence were as follows: slice thickness = 3 mm, echo time = 86 ms, repetition time = 8300 ms, b = 1000 s/mm2, field of view = 240 mm×240 mm, acquisition matrix = 128×128, and in-plane resolution = 2.2.×2.2 mm.
The DTI data were preprocessed by PANDA software [14] (link), following these steps: skull removal, correction of eddy-current distortion, and construction of FA maps. The FA maps generated for each patient were then transformed from individual space to a standard Montreal Neurological Institute (MNI) space via spatial normalization, and resliced with a voxel size of 2 mm×2 mm×2 mm. All FA maps were smoothed using an isotropic Gaussian filter with a full-width-at-half-maximum of 6 mm.
The DTI data were preprocessed by PANDA software [14] (link), following these steps: skull removal, correction of eddy-current distortion, and construction of FA maps. The FA maps generated for each patient were then transformed from individual space to a standard Montreal Neurological Institute (MNI) space via spatial normalization, and resliced with a voxel size of 2 mm×2 mm×2 mm. All FA maps were smoothed using an isotropic Gaussian filter with a full-width-at-half-maximum of 6 mm.
Free full text: Click here
