The intervention is designed to support patients with CNCP to taper and reduce their opioid use, promoting increased self-management of pain. The goal is harm reduction where cessation is not possible, and the pilot will be aimed at reducing opioid use to within safe levels. Harm reduction refers to general opioid use and potential harms for participating in the study. The intervention is underpinned by psychological theory59–61 (link) and delivered using validated behaviour change techniques.62 (link) The intervention will be delivered by trained specialists (pharmacists/nurse prescribers) during an appointment and comprises a structured dose reduction prescribing protocol for opioids, education about harms, including worsening pain, withdrawal symptoms, decreased tolerance and risk of overdose and overdose death from both prescribed and over the counter medications if used inappropriately, alongside brief advice supported by written and online materials. During the face-to-face sessions, AHPs will offer emotional, informational and instrumental support to help patients self-manage their pain without opioids. The materials will be available on a range of media, with participants having access to video-based online media throughout the study. The study will also capitalise on and promote existing social prescribing mechanisms that are in place within Knowsley Place to further support patients’ self-management. A dedicated website has been set up (hosted by LJMU), which collates existing widely and freely available online resources for pain education and management.