MRI-Based Brain Structural Analysis Pipeline

Unless contraindicated, children underwent magnetic resonance imaging (MRI) using a Siemens Prisma^® (Siemens Medical Solutions, Malvern, PA), General Electric Discovery^™ MR750 (GE Healthcare, Chicago, IL), or Philips Achieva (Koninklijke Philips, Amsterdam, Netherlands) scanner. Standard adult coils provided high resolution images harmonized using the following settings: T1-weighted: MP-RAGE with 256×256 matrix size, 176 slices, 1 mm resolution in all axes, TR=6.31 ms, TE=2500 ms and TI=1060 ms; flip angle=8 deg; 2-fold parallel imaging; multiband off.^{12 (link)} Cortical thickness, area, and volume were calculated using a Freesurfer-based pipeline^{13 (link)} using the Destrieux atlas,^{14 (link)} which parcellated 74 cortical and subcortical brain regions/hemisphere. Cortical effect size maps were generated using Nilearn.^{15 (link)}

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Isaiah A., Ernst T.M., Liang H., Ryan M., Cunningham E., Rodriguez P.J., Menken M., Kaschak D., Guihen C., Reeves G., Lever N., Edwards S.M, & Chang L. (2022). Associations between socioeconomic gradients and racial disparities in preadolescent brain outcomes. Pediatric research, 94(1), 356-364.

Publication 2022

Siemens Prisma General Electric Discovery™ MR750 Philips Achieva

Adult Axes Brain hemisphere Children Cortical Electric Maps Prisma Rage

Corresponding Organization : University of Maryland, Baltimore

Other organizations : University of Hawaiʻi at Mānoa

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Variable analysis

independent variables

Not explicitly mentioned

dependent variables

Cortical thickness
Cortical area
Cortical volume

control variables

Scanner type (Siemens Prisma, General Electric Discovery MR750, or Philips Achieva)
Standard adult coils
T1-weighted: MP-RAGE with 256x256 matrix size, 176 slices, 1 mm resolution in all axes, TR=6.31 ms, TE=2500 ms and TI=1060 ms, flip angle=8 deg, 2-fold parallel imaging, multiband off

controls

No positive or negative controls were explicitly mentioned.

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