Scanning Electron Microscopy of Solid Formulations

The solid powder samples (pure CN, pure SYL, cured SYL [before SNEDDS loading]), and cured S-SNEDDS) were examined using a scanning electron microscope (Carl Zeiss EVO LS10, Cambridge, UK). S-SNEDDS were assessed in terms of morphological characteristics of the formulation and to detect signs of poor solidification attributes. Samples were coated with gold in a Q150R sputter coater unit (Quorum Technologies Ltd., Lewes, UK) under vacuum for 60 sec under 20 mA argon atmosphere [19 (link),25 (link)].

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Tashish A.Y., Shahba A.A., Alanazi F.K, & Kazi M. (2022). Adsorbent Precoating by Lyophilization: A Novel Green Solvent Technique to Enhance Cinnarizine Release from Solid Self-Nanoemulsifying Drug Delivery Systems (S-SNEDDS). Pharmaceutics, 15(1), 134.

Publication 2022

EVO LS10 Q150R sputter coater unit

Argon Atmosphere Gold Powder Scanning electron microscope Vacuum

Corresponding Organization : King Saud University

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Variable analysis

independent variables

Type of sample (pure CN, pure SYL, cured SYL [before SNEDDS loading], and cured S-SNEDDS)

dependent variables

Morphological characteristics of the formulation
Signs of poor solidification attributes

control variables

Sample preparation (coated with gold in a Q150R sputter coater unit under vacuum for 60 sec under 20 mA argon atmosphere)

controls

No positive or negative controls were explicitly mentioned.

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