Assessing GFR in Elderly Chinese Patients

Participants who were older than 60 years were selected to measure GFR at the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China from Jan 2005 to Dec 2011. Patients with acute kidney function deterioration, clinical edema, skeletal muscle atrophy, pleural effusion or ascites, malnutrition, amputation, heart failure or ketoacidosis were excluded from the study. Participants that were taking cimetidine or trimethoprim were excluded as well. No subject was being treated with dialysis at the time of the study. Exclusion criteria were described elsewhere [6] (link). CKD was diagnosed and categorized according to the National Kidney Foundation Disease Outcomes Quality Initiative (NKF-K/DOQI) clinical practice guidelines [7] (link). The institutional review board of the Third Affiliated Hospital of Sun Yat-sen University approved the study. Written informed consent was obtained from each participant. A total of 668 elderly participants were included in this study, including 398 men and 270 women. The mean age was 70.0±6.7 yr (ranged from 60 to 93 yr), and the mean measured GFR (mGFR) was 51.2±26.0 ml/min/1.73 m² (ranged from 6.6 to 134.1 ml/min/1.73 m²). Causes and GFR categories are listed in Table 1. The total cohort was randomly divided into the development data set (n = 433) and the validation data set (n = 235).