Left Atrial Access Screening Protocol

We screened a population who needed LA access as a part of a therapeutic procedure for AF or supraventricular tachycardia (Figure 1). From July 2015 to November 2016, 264 patients with AF were enrolled. The control group consisted of 35 patients with re-entry tachycardia via a left-side accessory pathway or left-origin atrial tachycardia. Patients with (1) previous cardiac surgery or procedure history (n = 0), (2) LV systolic dysfunction (LVEF < 50%) or structural heart disease including ischemic lesion (n = 15), (3) moderate to severe mitral and aortic valve disease (n = 0), (4) recurrent triggers, that induced sustained arrhythmias interrupting the maintain sinus rhythm (SR) (n = 1), and (5) AF induction during right atrial pacing (n = 14 in AF group and n = 1 in control group) were excluded via a screening test. A total of 204 patients in the AF group and 34 patients in the control group were finally analyzed (male 77.1%, 54.0 ± 12.4 years old). In addition, the cohort was divided into two groups based on the criteria of E/e’ = 8 (median value), which is an echocardiographic LV diastolic dysfunction marker. We compared 144 patients with low E/e’ and 124 patients with high E/e’. All patients provided written informed consent for inclusion in the cohort. The research protocol complied with the principles of the Declaration of Helsinki and was approved by the Institutional Review Board of the Korea University Anam Hospital.

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Roh S.Y., Lee D.I., Lee K.N., Ahn J., Baek Y.S., Kim D.H., Shim J., Choi J.I, & Kim Y.H. (2023). E/e’ Ratio Predicts the Atrial Pacing-Induced Left Atrial Pressure Response in Patients with Preserved Ejection Fraction. Medicina, 59(2), 210.

Publication 2023

A 204 Accessory pathway Af 14 Aortic valve disease Arrhythmias Cardiac surgery Echocardiographic Heart disease Institutional review board Left Left atrial Lv diastolic dysfunction Lv systolic dysfunction Male Patients Right atrial Sinus Supraventricular tachycardia Therapeutic procedure Triggers

Corresponding Organization : Korea University Medical Center

Other organizations : Chungbuk National University Hospital, Ajou University, Pusan National University Hospital, Inha University Hospital

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Variable analysis

independent variables

Left atrial (LA) access as a part of a therapeutic procedure for atrial fibrillation (AF) or supraventricular tachycardia

dependent variables

Presence of AF or re-entry tachycardia via a left-side accessory pathway or left-origin atrial tachycardia

control variables

Previous cardiac surgery or procedure history (n = 0)
LV systolic dysfunction (LVEF < 50%) or structural heart disease including ischemic lesion (n = 15)
Moderate to severe mitral and aortic valve disease (n = 0)
Recurrent triggers that induced sustained arrhythmias interrupting the maintain sinus rhythm (SR) (n = 1)
AF induction during right atrial pacing (n = 14 in AF group and n = 1 in control group)

positive controls

Control group consisting of 35 patients with re-entry tachycardia via a left-side accessory pathway or left-origin atrial tachycardia

negative controls

Exclusion of patients with previous cardiac surgery or procedure history (n = 0)
Exclusion of patients with moderate to severe mitral and aortic valve disease (n = 0)
Exclusion of patients with recurrent triggers that induced sustained arrhythmias interrupting the maintain sinus rhythm (SR) (n = 1)

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