ALS Lipid Prognostic Factors

We conducted the systematic search in 4 literature databases: PubMed, EMBASE, DARE, and the Cochrane Library; the study protocol for the systematic review is presented in the supplementary material (eAppendix 1: Systematic Review Protocol,, links.lww.com/WNL/C516). Additional forms or information, such as data collection forms, can be provided on request. The primary purpose of the meta-analyses was to provide an explanatory summary of the current literature. All databases were last searched in June 2022. Search terms included the MeSH terms: “Amyotrophic Lateral Sclerosis”; “Motor Neuron Disease”; “Cholesterol”; “Cholesterol, LDL”; “Cholesterol, HDL”; “Triglyceride”; “Lipid”; “Prognosis”; “Survival”; “Mortality”; “Kaplan-Meier estimate”; and “Proportional Hazard Models.” Studies were selected on the basis of the following inclusion criteria: (1) participants diagnosed with ALS according to the revised El Escorial criteria (EEC)¹⁷ ; (2) reporting of at least one of the following measurements: TC, HDL-C, LDL-C, or TG, obtained after symptom onset; (3) reporting of survival time and hazard ratio (HR); and (4) written in English or Dutch. Study eligibility was not based on sample size. All articles were screened independently by 2 reviewers for title and abstract (M.J.v.M. and A.H.). Included and excluded articles were discussed; if no consensus was reached, a third reviewer was consulted (R.P.A.v.E.).