Synthesis and Evaluation of Auranofin Metabolites

Aurocyanide (Gold(I) potassium cyanide) was purchased from Alfa Aesar (Ward Hill, MA, USA). l-thio-3-D-glucopyranosato-(triethylphosphine) gold(I) (M1) was synthesized from chloro(triethylphosphine) gold(I) and the thiosugar. Other proposed metabolites of auranofin (M2-M6) were obtained from Sigma (St. Louis, MO, USA). Recombinant human transforming growth factor-β1 (TGF-β1) was supplied by PeproTech (Cranbury, NJ, USA). TAA, lipopolysaccharide (LPS), and adenosine triphosphate (ATP) were purchased from Sigma (St. Louis, MO, USA).

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Kim H.Y., Otgontenger U., Kim J.W., Lee Y.J., Kim S.B., Lim S.C., Kim Y.M, & Kang K.W. (2023). Anti-fibrotic effect of aurocyanide, the active metabolite of auranofin. Archives of Pharmacal Research, 46(3), 149-159.

Publication 2023

Recombinant human transforming growth factor-β1 (TGF-β1) lipopolysaccharide (LPS), adenosine triphosphate (ATP)

Adenosine triphosphate Auranofin Aurocyanide Gold Human Lipopolysaccharide Potassium cyanide Recombinant transforming growth factor β1 Thiosugar

Corresponding Organization :

Other organizations : Seoul National University, Hanyang University, Daegu-Gyeongbuk Medical Innovation Foundation, Chosun University

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Variable analysis

independent variables

Aurocyanide (Gold(I) potassium cyanide)
L-thio-3-D-glucopyranosato-(triethylphosphine) gold(I) (M1)
Other proposed metabolites of auranofin (M2-M6)
Recombinant human transforming growth factor-β1 (TGF-β1)
Lipopolysaccharide (LPS)
Adenosine triphosphate (ATP)

dependent variables

Measured outcomes

control variables

Kept constant to ensure valid results

controls

Positive controls
Negative controls

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