Chordoma PDX Models for In Vivo Studies

Three previously established and characterized chordoma PDXs were used for in vivo experiments: cluster of differentiation (CD) 3, CD7, and CD39 (35 (link)). The main clinical, histological, and genomic features of our xenografts panel have been previously described (35 (link)). PDX models of chordomas were obtained by engrafting a primary tumor sample into nude mice (Charles River Laboratories). All in vivo experimental procedures, animal care, and housing were performed in accordance with the recommendations of the European Community (2010/63/UE) for the care and use of laboratory animals. Experimental procedures were specifically approved by the ethics committee of the Institut Curie CEEA-IC #118 (Authorization APAFiS# 25870-2020060410487032-v1 given by National Authority) in compliance with the international guidelines.